Synthesis and Antimicrobial Studies of Iron (iii) Complexes of Ciprofloxacin, Penicillins and Isatin Derrivative by Eze Fabian Ifeanyi Pg/ M.sc/07/43054 Department of Pharmaceutical and Medicinal Chemistry Faculty of Pharmaceutical Sciences University of Nigeria, Nsukka

نویسندگان

  • Fabian Ifeanyi
  • N. J. Nwodo
چکیده

Complexation is very relevant in pharmacy as a means of modifying the pharmacological, toxicological and physicochemical properties of drugs.In this study, iron (III) complexes of ciprofloxacin, ampicillin, amoxicillin, and cloxacillin were synthesized through systematic choice of solvents and reaction conditions. A Schiff base derived from Isatin (Indole-1,2-dione) and ethylenediamine, and its iron (III) complex were also synthesized. The aqueous solubility profiles of the complexes were determined. The complexes showed improved aqueous solubility when compared to those of the corresponding ligands. Relative thermal and acid stabilities were determined spectrophotometrically. Results showed that the complexes have enhanced thermal and acid stabilities with respect to the pure ligands. Antimicrobial studies

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Synthesis, Physicochemical Properties, and Antimicrobial Studies of Iron (III) Complexes of Ciprofloxacin, Cloxacillin, and Amoxicillin

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تاریخ انتشار 2012